Early in her career she co-founded Womyn Image Makers (WIM), a queer Latina-identified film collective based out of Los Angeles. While with WIM, she directed short films including Pura Lengua and Viernes Girl. Her work earned her a slot on FILMMAKER MAGAZINE'S 25 Faces to Watch. Guerrero wrote and directed Mosquita Y Mari, her debut narrative feature film, which premiered at the 2012 Sundance Film Festival. Mosquita Y Mari went on to travel top-tier film festivals including San Francisco, Melbourne, Goteburg, and Guadalajara while garnering multiple awards including Best First Narrative Feature at Outfest. Mosquita y Mari was nominated for the Cassavetes Spirit Award and a GLAAD Media Award. In 2017, Guerrero directed her first episode of television on Ava Duvernay's critically acclaimed drama, Queen Sugar. Since she has directed on Greenleaf, Gentefied, Little America, 13 Reasons Why, and Duvernay's latest, Cherish The Day.